International Journal of Infectious Diseases and Therapy

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Ciprofloxacin-Induced Thrombocytopenia: A Case Report and Literature Review

Background: Drug induced thrombocytopenia is associated with several usual drugs. It usually presents with stunning, chills, fever, nausea and vomiting followed by the occurrence of petechial hemorrhages and bruising. Fluoroquinolones which are a widely used antibiotics are not recognized to be common offenders. Ciprofloxacin is generally considered a safe and well-tolerated drug. It has a large spectrum and it is one of the most widely prescribed antibiotics in a broad range of infections. Purpose: Only a few cases of fluoroquinolone-induced thrombocytopenia have been reported thus this side effect is largely unknown by clinicians. Case: We report the case of a 55 year old women with a bilateral percutaneous nephrostomy secondary to a radiation-induced cystitis. She was known for chronic kidney disease KDIGO IIIb and arterial hypertension. She suffered severe thrombocytopenia on three different occasions while treated by ciprofloxacin for urinary infections. She remained asymptomatic although her platelet count dropped as low as 6×103/µL. Each time, her platelet count recovered within a few days after ciprofloxacin interruption. Conclusion: Clinicians should be aware of the possible relationship between thrombocytopenia and ciprofloxacin. In depth work-up should be carried out to assess relationship between a newly introduced drug and a serious clinical or biological side effect.

Ciprofloxacin, Thrombocytopenia, Drug Induced Toxicity, Antibiotic Toxicity, Hematologic Toxicity

APA Style

Alexis Orman, Mohamed Tayeb Salaouatchi, Anne Demulder, Juliette Coryn, Victor Fernando Calderon Plazarte, et al. (2023). Ciprofloxacin-Induced Thrombocytopenia: A Case Report and Literature Review. International Journal of Infectious Diseases and Therapy, 8(3), 122-126.

ACS Style

Alexis Orman; Mohamed Tayeb Salaouatchi; Anne Demulder; Juliette Coryn; Victor Fernando Calderon Plazarte, et al. Ciprofloxacin-Induced Thrombocytopenia: A Case Report and Literature Review. Int. J. Infect. Dis. Ther. 2023, 8(3), 122-126. doi: 10.11648/j.ijidt.20230803.17

AMA Style

Alexis Orman, Mohamed Tayeb Salaouatchi, Anne Demulder, Juliette Coryn, Victor Fernando Calderon Plazarte, et al. Ciprofloxacin-Induced Thrombocytopenia: A Case Report and Literature Review. Int J Infect Dis Ther. 2023;8(3):122-126. doi: 10.11648/j.ijidt.20230803.17

Copyright © 2023 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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