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Research Article |

Hematological Profile of Malaria Patients at the Southeast Minahasa, North Sulawesi, Indonesia

Malaria remains a public health concern in Indonesia. Several types of district and private hospitals play a very important role in treating malaria sufferers and their complications. Hematological alterations are the most prevalent consequences of malaria. Therefore, this study aimed to compile a hematological profile of malaria patients treated at Mitra Sehat Regional General Hospital, Southeast Minahasa Regency, North Sulawesi, Indonesia. A total of 92 patients with clinical symptoms of fever and positive for malaria after examining their peripheral blood smear, were included in this cross-sectional study. The data from the hematology examination was then analyzed. There were 65 cases caused by P. falciparum, followed by 21 cases of P. vivax, and 6 cases of P. falciparum and P. vivax co-infection. The most frequent hematological abnormality seen in malaria patients in this study was thrombocytopenia (91%). Furthermore, leukopenia was found in 33%, followed by anemia in 20%. While females had greater levels of white blood cells and platelets count, male patients had significantly higher averages for hemoglobin, red blood cells count, and hematocrit profiles. In conclusion, the hematological alterations associated with malaria patients include thrombocytopenia, leukopenia, and anemia, therefore people living in highly endemic locations, like Southeast Minahasa, can use these markers to strengthen their suspicion of malaria.

Malaria, Plasmodium, Anemia, Leukopenia, Thrombocytopenia

APA Style

Shintawati Purwanto, D., Merry Eva Mamahit, J. (2023). Hematological Profile of Malaria Patients at the Southeast Minahasa, North Sulawesi, Indonesia. International Journal of Infectious Diseases and Therapy, 8(4), 146-149.

ACS Style

Shintawati Purwanto, D.; Merry Eva Mamahit, J. Hematological Profile of Malaria Patients at the Southeast Minahasa, North Sulawesi, Indonesia. Int. J. Infect. Dis. Ther. 2023, 8(4), 146-149. doi: 10.11648/j.ijidt.20230804.15

AMA Style

Shintawati Purwanto D, Merry Eva Mamahit J. Hematological Profile of Malaria Patients at the Southeast Minahasa, North Sulawesi, Indonesia. Int J Infect Dis Ther. 2023;8(4):146-149. doi: 10.11648/j.ijidt.20230804.15

Copyright © 2023 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

1. Jiero S, Pasaribu AP. Haematological profile of children with malaria in Sorong, West Papua, Indonesia. Malar J. 2021; 20(1): 126.
2. Awoke N, Arota A. Profiles of hematological parameters in Plasmodium falciparum and Plasmodium vivax malaria patients attending Tercha General Hospital, Dawuro Zone, South Ethiopia. Infect Drug Resist. 2019; 12: 521-7.
3. Kementerian Kesehatan Republik Indonesia. Kasus Malaria Indonesia Melonjak 36, 29% pada 2022 [Internet]. Available from:
4. Purwanto DS, Ottay RI. Profil penyakit malaria pada penderita rawat inap di Rumah Sakit Umum Daerah Kota Bitung. J Biomedik. 2013; 3(3): 172-8.
5. Pinontoan OR, Punuh MI. Malarial risk factor identification in southern Minahasa, North Celebes Manado-Indonesia. Bali Med J. 2017; 6(2): 440-4.
6. Kotepui M, Phunphuech B, Phiwklam N, Chupeerach C, Duangmano S. Effect of malarial infection on haematological parameters in population near Thailand-Myanmar border. Malar J. 2014; 13(1): 218.
7. Omarine Nlinwe N, Nange TB. Assessment of hematological parameters in malaria, among adult patients attending the Bamenda Regional Hospital. Anemia. 2020; 2020: 1-8.
8. Kumbhar SS, Kanetkar SR, Mane A, Agarwal G, Bansal S. Clinico-hematological profile of malaria cases in a tertiary care hospital. Galore Int J of Health Sci and Research. 2019; 4(3): 79-89.
9. Tafesse T, Amenu D. A retrospective analysis of malaria prevalence from 2015 to 2020 in Sibu Sire Woreda, East Wollega Zone, and Western Ethiopia. Int J Appl Biol; 2022; 6(2): 56-64.
10. Gebreweld A, Erkihun Y, Feleke DG, Hailu G, Fiseha T. Thrombocytopenia as a diagnostic marker for malaria in patients with acute febrile illness. J Trop Med. 2021; 2021: 1-6.
11. Latif I, Jamal A. Hematological changes in complete blood picture in paedriatric patients of malaria caused by Plasmodium vivax and falciparum. J Ayub Med Coll Abbottabad. 2015; 27(2): 351–5.
12. Maina RN, Walsh D, Gaddy C, Hongo G, Waitumbi J, Otieno L, et al. Impact of Plasmodium falciparum infection on haematological parameters in children living in Western Kenya. Malar J. 2010; 9(S3): S4.
13. Aggarwal R, Chaturvedi V, Kumar Singh S, Pandey P, Agarwal S, Singh J. Effect of malaria parasite on haematological parameters: an institutional experience. Medico-Leg Update. 2020; 20(4): 472-7.
14. Sakzabre D, Asiamah EA, Akorsu EE, Abaka-Yawson A, Dika ND, Kwasie DA, et al. Haematological profile of adults with malaria parasitaemia visiting the Volta Regional Hospital, Ghana. Adv Hematol. 2020; 2020: 1-6.