Ciprofloxacin-Induced Thrombocytopenia: A Case Report and Literature Review:: Science Publishing Group

Ciprofloxacin-Induced Thrombocytopenia: A Case Report and Literature Review

Alexis Orman¹, Mohamed Tayeb Salaouatchi¹, Anne Demulder², Juliette Coryn¹, Victor Fernando Calderon Plazarte³, André Efira⁴, Philippe Clevenbergh⁵

¹Internal Medicine Department, University Hospital Brugmann, Université Libre de Bruxelles (ULB), Brussels, Belgium

²Hematology Laboratory, Universitary Laboratorium Brussel (LHUB-ULB), University Hospital Brugmann, Brussels, Belgium

³Urology Clinic, University Hospital Brugmann, Université Libre de Bruxelles (ULB), Brussels, Belgium

⁴Hematology Oncology Clinic, University Hospital Brugmann, Université Libre de Bruxelles (ULB), Brussels, Belgium

⁵Infectious Diseases Clinic, University Hospital Brugmann, Université Libre de Bruxelles (ULB), Brussels, Belgium

International Journal of Infectious Diseases and Therapy, Volume 8, Issue 3, September 2023

Pages: 122-126

Received: Jul. 27, 2023

Accepted: Aug. 24, 2023

Published: Sep. 13, 2023

DOI: 10.11648/j.ijidt.20230803.17

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Abstract

Background: Drug induced thrombocytopenia is associated with several usual drugs. It usually presents with stunning, chills, fever, nausea and vomiting followed by the occurrence of petechial hemorrhages and bruising. Fluoroquinolones which are a widely used antibiotics are not recognized to be common offenders. Ciprofloxacin is generally considered a safe and well-tolerated drug. It has a large spectrum and it is one of the most widely prescribed antibiotics in a broad range of infections. Purpose: Only a few cases of fluoroquinolone-induced thrombocytopenia have been reported thus this side effect is largely unknown by clinicians. Case: We report the case of a 55 year old women with a bilateral percutaneous nephrostomy secondary to a radiation-induced cystitis. She was known for chronic kidney disease KDIGO IIIb and arterial hypertension. She suffered severe thrombocytopenia on three different occasions while treated by ciprofloxacin for urinary infections. She remained asymptomatic although her platelet count dropped as low as 6×10³/µL. Each time, her platelet count recovered within a few days after ciprofloxacin interruption. Conclusion: Clinicians should be aware of the possible relationship between thrombocytopenia and ciprofloxacin. In depth work-up should be carried out to assess relationship between a newly introduced drug and a serious clinical or biological side effect.

Keywords

Ciprofloxacin, Thrombocytopenia, Drug Induced Toxicity, Antibiotic Toxicity, Hematologic Toxicity

To cite this article

Alexis Orman, Mohamed Tayeb Salaouatchi, Anne Demulder, Juliette Coryn, Victor Fernando Calderon Plazarte, et al. (2023). Ciprofloxacin-Induced Thrombocytopenia: A Case Report and Literature Review. International Journal of Infectious Diseases and Therapy, 8(3), 122-126. https://doi.org/10.11648/j.ijidt.20230803.17

Copyright © 2023 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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